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Make sure that the area (s) are dry then place a thick amount of toothpaste on it and repeat this for 3-5 days. Mupirocin is used in particular to treat infections caused by bacteria called meticillin-resistant Staphylococcus aureus (MRSA). People use Bactroban topical (for use on the skin) for treating skin infections like impetigo (also called Staph). Aureus has been historically the predominant gram-positive bacteria in ESI.. 1k views Reviewed >2 years ago Thank Dr. Bat Read More Created for people with ongoing healthcare needs but benefits everyone. I would decolonize using bactroban, but after a couple months it keeps coming back, now its not responding as good to the cream. Aureus has been focused on preventing cross-infection between patients, however, it has been shown repeatedly that a large proportion of nosocomial S. Bactroban, also known as mupirocin, is an antibiotic that arrests the growth of bacteria on the skin. 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Aureus, the use of mupirocin ointment results in a statistically significant reduction in S. Reoccurring staph infections from overcolonized nose happening on face (swabbed, not MRSA). Usual Pediatric Dose for Nasal Carriage of Staphylococcus aureus: 12 years or older:. Bactroban (mupirocin) is a topical antibiotic used to treat superficial skin infections such as impetigo and staph. Neosporin can also help, but if its staph a dr needs to see and treat it. Bactroban Cream Dosage and Administration • For Topical Use Only. Bactroban topical (for use on the skin) is used to treat skin infections such as impetigo or a "Staph" infection of the skin. Perhaps you are allergic to the bactroban (mupirocin) ointmnet. The ointment is called Bactroban (Mupirocin). 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